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TWO CASES OF INFLTJENZAL MENINGITIS — PATIENTS TREATED WITH HEXAMETHYLENAMIN

WALTER V. BREM, M.D.; A. H. ZEILER, M.D.
Am J Dis Child. 1911;I(6):417-430. doi:10.1001/archpedi.1911.04100060026002.
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In a former communication1 one of us reported a case of meningococcus meningitis treated with hexamethylenamin. This treatment was suggested by the work of Crowe,2 who showed that the drug appeared in considerable quantity in the cerebrospinal fluid shortly after administration. In the case reported there appeared to be some benefit derived from the treatment, and hexamethylenamin could be readily demonstrated by Hehner's test in the fluid from lumbar puncture, even when diluted forty times. The patient lived twenty-six days, although the attack was very acute. This experience led us to use hexamethylenamin in the treatment of two subsequent cases of influenzal meningitis. The quantities used were relatively much larger than in the case of meningococcus meningitis, for we were influenced by the work of Frothingham,3 who showed by experiments on animals that larger quantities could probably be used with safety.

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