0
Other Articles |

PLASMA PROTHROMBIN IN INFANTILE DIARRHEA

Y. MATOTH, M.D.; E. Heiman-Hollander; K. Galewski
AMA Am J Dis Child. 1950;80(6):944-954. doi:10.1001/archpedi.1950.04040020959007.
Text Size: A A A
Published online

THE BOWEL is the site of absorption of vitamin K and its synthesis by micro-organisms. Pathological states in the alimentary canal may therefore be reflected in a lowered plasma prothrombin level. Hypoprothrombinemia of enteral origin is known to occur in severe protracted diarrhea1 and in several other conditions, all having in common an impairment of intestinal absorption.2

Interest in prothrombin in the pediatric literature has centered around hemorrhagic disease of the newborn. In older infants no marked difference in prothrombin activity from that in adults and older children has been noted. Rapoport and Dodd3 observed a prolongation of prothrombin time in seven infants with chronic diarrhea and drew attention to the apparently not infrequent occurrence of hypoprothrombinemia in infants suffering from this condition.

Animal experiments4 and experience with human beings5 have shown that hypoprothrombinemia may result from the use of sulfaguanidine, succinylsulfathiazole and orally administered

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();