This book is a monograph on hemolytic disease of the newborn based on 116 affected children of 73 families from the Radcliffe Infirmary in Oxford, England. The historical evolution of the disease is given in considerable detail, and the author has set down most of the steps that went toward the final analysis of this condition. The antigens, immunization, pattern of disease and treatment are discussed in detail. The pathology is illustrated with examples from the author's own cases. The final chapter is devoted to the sequelae and other manifestations of the disease. An appendix deals rather fully with the actual serologic technics involved. The literature concerning this condition has been well reviewed, and a fair analytic study has been made of the accepted procedures.