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AMA Am J Dis Child. 1950;80(5):767-778. doi:10.1001/archpedi.1950.04040020781005.
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COOLEY and Lee1 in 1925 described a series of patients with anemia, splenomegaly and changes in the bones which made up a disease entity that became known as "Cooley's anemia," "Mediterranean anemia," "erythroblastic anemia" or "thalassemia."la

Gradually, the term Mediterranean anemia has become most widely used to describe this condition, since the disease is primarily found in the offspring of families native to areas adjoining the Mediterranean Sea. Other important manifestations of the disease include its familial nature, the presence of "target cells," a blood picture which is hypochromic and microcytic, conspicuous variation in the size of the red cells and increased resistance of the erythrocytes in hypotonic sodium chloride solutions. However, certain variations have been observed in this disease picture, and it is the purpose of this communication to report a series of cases of major and minor forms of Mediterranean anemia occurring in children of non-Mediterranean


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