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Case Reports |

EHLERS-DANLOS SYNDROME

JOSEPH T. FREEMAN, M.D.
Am J Dis Child. 1950;79(6):1049-1056. doi:10.1001/archpedi.1950.04040011068006.
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The syndrome of Ehlers and Danlos apparently is a constitutional dyscrasia of the mesenchyma, characterized by specific manifestations in the skin, joints and subcutaneous tissue, often associated with other congenital defects.

Its history was initiated in 1899 when Ehlers reported on a patient to the Danish Dermatologic Society.1 With the turn of the century, Morris made an indefinite presentation of a similar patient at a meeting of the Old Dermatological Society of London.2 Six years later, in 1906, Hallopeau and Macé de Lépinay described the condition under the name of pseudodiabetic xanthoma.3 Shortly thereafter, Cohn defined the pattern quite as it is recognized today.4 In 1908, Danlos reviewed the case presented in 1906, recognized the unusual basic manifestations, corrected the misleading impressions given by the original authors in their descriptive title and, like Ehlers and Cohn, outlined the new syndrome.5 The first report on the

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