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DETERMINATION OF HEMOGLOBIN CONCENTRATION IN PREMATURE INFANTS BY THE CYANMETHEMOGLOBIN METHOD

MAKEPEACE U. TSAO, Ph.D.; HELEN S. REARDON, M.D.
Am J Dis Child. 1950;79(4):673-675. doi:10.1001/archpedi.1950.04040010688007.
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THE VALIDITY of methods for the determination of hemoglobin concentration in adults when applied to newborn infants has been questioned. This question arises because of the demonstration by many investigators of differences in chemical and physical properties between adult and fetal hemoglobin; these are, to name a few, the crystallographic characteristics,1 the resistance against denaturation in strong alkali2 and the affinity with oxygen.3 It has been shown by Jonxis4 that fetal hemoglobin is replaced by adult hemoglobin in the blood of newborn infants at a relatively slow rate except in the cases of erythroblastosis; there is yet some controversy about the rate in this disease.5 However, there is no question about the presence of a considerable proportion of fetal hemoglobin in newborn full term and in premature infants.

It was the purpose of this investigation to determine whether the cyanmethemoglobin method is applicable to both

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