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March 1950, Vol 79, No. 3 >
Other Articles | March 1950

A PEDIGREE OF CLUBFOOT

JAMES V. NEEL, Ph.D., M.D.; HAROLD F. FALLS, M.D.; AVERY R. TEST, Ph.D.
Am J Dis Child. 1950;79(3):442-448. doi:10.1001/archpedi.1950.04040010455004.
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THE VARIOUS forms of clubfoot, a deformity occurring with a frequency of about 1 per 1,000 live births,1 constitute one of the commonest of congenital abnormalities. Almost invariably, the mother of a child so affected wishes to know the probability of a similar outcome in subsequent pregnancies. Although the majority of cases are isolated occurrences, a detailed family history reveals the presence of other similarly afflicted persons in 15 to 20 per cent of the families.2 In those instances in which the family history is positive, as many as 7, 8 or, even, 11 affected persons distributed in an apparently regular or irregular fashion over three or four generations have been reported.3 In cases in which a child with congenital clubfoot has been born to normal parents, the probability of a recurrence of this event in any subsequent pregnancy can be placed at about 0.03.4 It

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