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CUSHING'S SYNDROME DUE TO TUMOR OF ADRENAL CORTEX Report of a Case of An Eleven Month Old Infant, with Apparent Operative Cure

Am J Dis Child. 1949;78(2):260-278. doi:10.1001/archpedi.1949.02030050271012.
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DISEASES of the adrenal cortex have attracted widespread attention in the medical literature since ancient times because of the dramatic character of the clinical syndromes they produce. The adrenocortical syndrome has been frequently reviewed (Bulloch and Sequeira, 1905; Glynn, 1911-1912; Haymaker and Anderson, 1938; Reilly, Lisser and Hinman, 1939; Marks, Thomas and Warkany, 1940; Farber, Gustina and Postoloff, 1943; Goldstein, Rubin and Askin, 1946; Wilkins, 1948). In children, the clinical manifestations of hyperfunction of the adrenal cortex vary with the age and sex of the patient, as well as with the hormonal production of the hyperfunctioning cells. Prenatally, hyperplasia of the adrenal cortex may cause virilization of the external genitalia of female infants or female pseudohermaphrodism (Young, 1937). This condition is compatible with a normal, although sometimes confused, lifespan. In rare instances female pseudohermaphrodism may be associated with an adrenocortical tumor (Krabbe, 1921; Scabell, 1925). The metabolic changes of Cushing's


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