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TREATMENT OF INFANTILE CONGENITAL SYPHILIS:  Results with Aqueous Penicillin Alone in Sixty Infants Followed for an Average of Two Years After Treatment

ELIZABETH KIRK ROSE, M.D.; PAUL GYÖRGY, M.D.; NORMAN R. INGRAHAM Jr., M.D.
Am J Dis Child. 1949;77(6):729-735. doi:10.1001/archpedi.1949.02030040744003.
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IN THE treatment of the infant with congenital syphilis, general experience to date has proved penicillin the most satisfactory therapeutic agent. Long term follow-up reports, however, have been lacking, and it is for this reason that our study, based on results in 60 infants1 followed over an average of two years, is presented. Previously, seemingly adequate antisyphilitic therapy in infancy has been followed by late relapses, the development of paresis or interstitial keratitis.

A previous report2 discussed selection of cases, dosages, reactions, complications, deaths and immediate response to treatment. This report concerns itself more with long term observation of whether or not clinical or serologic relapses may take place in spite of initial clinical improvement and whether or not any other complications or sequelae of congenital syphilis may occur.

RESULTS OF TREATMENT  Table 1 shows an analysis of the age at onset of therapy in the 55 patients

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