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May 1949, Vol 77, No. 5 >
Case Reports | May 1949

DIABETES MELLITUS ASSOCIATED WITH MONGOLISM:  A Case of a Child Two Years of Age

HARRY G. JACOBI, M.D.; JULIAN L. ROGATZ, M.D.
Am J Dis Child. 1949;77(5):659-661. doi:10.1001/archpedi.1949.02030040673009.
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THE COMBINATION of mongolism and diabetes poses an interesting and unusual problem. According to the available reported observations with respect to carbohydrate metabolism in mongolism,1 there occurs a definitely delayed glycemic response in this condition. Such a delayed glycemic response has been repeatedly demonstrated by means of dextrose tolerance tests. These were invariably characterized by low, absent or delayed peaks in the concentration of the blood sugar following the ingestion of the dextrose. With advancing age, these mongolian idiots showed this tendency in increasingly more pronounced form. The onset of diabetes at the age of 2 years being in itself quite uncommon, the combination of this condition with mongolism is a most unusual occurrence and probably acounts for the rarity of reports of such cases in the literature.

Lawrence,2 who reported on the only 3 patients we could find on record, was of the opinion that his were the

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