AGENESIS OF CORPUS CALLOSUM IN INFANCY: CLINICAL AND ROENTGENOLOGIC ASPECTS

CONGENITAL ABSENCE of the corpus callosum and the anomalies that occur in association with this condition have been the subjects of many studies since the first description of this entity by Reil¹ in 1812. In 1922 Mingazzini² collected 71 cases in his classic monograph on the corpus callosum. Baker and Graves³ in 1933 collected an additional 11 cases. To date, well over 100 cases have been reported. Until 1934 it was uniformly recorded as an incidental observation at necropsy. Davidoff and Dyke⁴ and Penfield and Hyndman⁵ were the first to establish the criteria for the pneumoencephalographic diagnosis of agenesis of the corpus callosum. Twenty-two cases have been diagnosed by roentgenologic means, 10 of which were confirmed by necropsy studies or at operation. More adequate opportunities were thus afforded for accurate study of the clinical aspects of these cases and for better classification of some of