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CHEMICAL STUDIES IN CHILDREN WITH THE NEPHROTIC SYNDROME

SIDNEY P. GOTTFRIED, Ph.D.; JOHN F. STEINMAN, M.D.; BENJAMIN KRAMER, M.D.
Am J Dis Child. 1947;74(3):283-304. doi:10.1001/archpedi.1947.02030010292003.
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THE BLOOD chemistry in nephrosis has been extensively studied by many investigators. Recent advances in knowledge of protein and lipid metabolism and parenteral replacement of protein have suggested new approaches to this still refractory disorder. In the light of this newer knowledge, we have attempted to reexamine the chemical data obtained during the course of the disease, to correlate these results with the clinical observations and to evaluate the effect of various therapeutic agents on the clinical and chemical course of the disease.

Ten patients presenting the nephrotic syndrome were studied over a period of two years, and the chemical data observed during the course of the disease are reported here. These patients were children between the ages of 16 months and 5 years, and included 8 boys and 2 girls. The term "nephrosis" is used in this paper to denote a disorder in which albuminuria, hypoproteinemia and edema are

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