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RELATION OF ASCORBIC ACID TO EFFECTIVENESS OF IRON THERAPY IN CHILDREN

HAZEL VERN SCHULZE, Ph.D.; AGNES FAY MORGAN, Ph.D.
Am J Dis Child. 1946;71(6):593-600. doi:10.1001/archpedi.1946.02020290016002.
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THERE are numerous studies published and in progress on the interaction of vitamins and regeneration of hemoglobin, and among these are some which involve the use of ascorbic acid. No definite conclusions have been reached, however, as to the true relationship of ascorbic acid to the metabolism of iron or its effectiveness in regeneration of hemoglobin.

The anemia which accompanies scurvy indicates a positive relationship, but whether this condition directly results from the ascorbic acid deficiency is questionable. Several investigators support this contention.1 Observation of the extensive changes in the bone marrow in scurvy would emphasize this possibility. Other investigators have reported studies in which anemia was not always found in scurvy2 or in which it might be ascribed to a generally deficient diet in which other substances than ascorbic acid were lacking or in which it might be due to the hemorrhage of scurvy.

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