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Am J Dis Child. 1945;70(5):325-328. doi:10.1001/archpedi.1945.02020230065011.
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Vague gastrointestinal complaints in children have always been a problem for the pediatrician. With the idea that these symptoms might occasionally be associated with disease of the gallbladder we have often desired to attempt cholecystography, but, owing to the toxic effects which at times follow the use of iodophthalein sodium for adults, it was felt that the use of this medium might be a dangerous procedure, especially for small persons.

Graham and Cole1 mentioned using cholecystography with iodophthalein sodium for a few children but mentioned no specific age or definite results. John Caffey2 stated that the youngest patient whose gallbladder was satisfactorily visualized by him with iodophthalein was 3½ years old and that in the few infants examined there was no evidence of accumulation of dye in the biliary tract. Little else on visualization of the gallbladder in children has appeared in the literature. Boyden and Fuller3


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