October 1944, Vol 68, No. 4 >

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THE BONE MARROW AS AN ALTERNATE ROUTE FOR TRANSFUSION IN PEDIATRICS

HENRY A. REISMAN, M.D.; IRVING A. TAINSKY, M.D.

Am J Dis Child. 1944;68(4):253-256. doi:10.1001/archpedi.1944.02020100025006.

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Henning¹ was the first to use the bone marrow as a route for transfusion. He tried to visualize the structure of the sternal bone marrow by the injection of watery contrast substances, such as abrodil (monoiodomethane sulfonic acid) and iopax (sodium salt of α-oxo-β-iodopyridine-N-acetic acid), and failed because of the comparative density of the sternum. On the other hand, postmortem experiments showed that the presence of contrast substances could be noted in both internal mammary veins after injection into the sternal bone marrow. When denser contrast substances, such as iodized sesame oil, were injected into the sternum, they were visualized roentgenologically. It was found that substances injected into the bone marrow entered the general circulation apparently unchanged and almost as rapidly as when injected intravenously. Tocantins and his associates² have shown that when mercury is injected into the bone marrow the metal may be seen by fluoroscopy to

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REISMAN HA, TAINSKY IA. THE BONE MARROW AS AN ALTERNATE ROUTE FOR TRANSFUSION IN PEDIATRICS. Am J Dis Child. 1944;68(4):253-256. doi:10.1001/archpedi.1944.02020100025006.

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