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Case Reports |

EPIPHYSIAL DYSGENESIS ASSOCIATED WITH CRETINISM IN A PREMATURE INFANT

MAURICE L. BLATT, M.D.; MARY ZELDES, M.D.; JAMES GOODFRIEND, M.D.
Am J Dis Child. 1944;67(6):480-484. doi:10.1001/archpedi.1944.02020060053009.
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In 1927 Fairbank1 described "stippled epiphyses" associated with dwarfism, but he failed to recognize thyroid deficiency as the basis of the disturbance. Ten years later (1937) Reilly and Smythe2 described 5 similar cases, designating the condition as "cretinoid epiphysial dysgenesis." McCullough and Sutherland3 in 1940 described stippled epiphyses in a dwarf in whom there was no sign of hypothyroidism and used the term "epiphysial dysplasia puncticularis" to designate the skeletal change. The patient was not given thyroid, but McCullough and Sutherland stated that he increased in stature when treated with calcium, vitamin D and androgen. Wilkins,4 who found bilateral epiphysial dysgenesis in 23 of 25 children with hypothyroidism, said that he had never seen true dysgenesis in any type of dwarfism other than that occurring with hypothyroidism. In his extensive review of the subject he cited reports of 36 cases observed by Läwen,5 Roth,6

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