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Case Reports |


Am J Dis Child. 1944;67(4):290-293. doi:10.1001/archpedi.1944.02020040046007.
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From the ill defined group of conditions known as von Jaksch's anemia, Cooley1 in 1927 separated a type of anemia which occurred in children which he regarded as a clinical entity and which presented characteristic clinical, roentgenologic and microscopic features. He reported that clinically children with this disease exhibited splenomegaly, muddy, yellowish discoloration of the skin and mongoloid facies, due to abnormal prominence of the malar bones. The patients were invariably of Greek, Italian or Syrian stock. Roentgenologically, osseous dystrophy, with thickening and sponginess of the bones, was a characteristic feature; microscopically, there was evidence of hemolytic (hypochromic) anemia, with an unusually large number of nucleated red cells in the blood. Cooley stressed the ancestry of these children, and it came to be believed that this type of anemia was almost exclusively confined to children of Mediterranean stock, so much so that one of the synonyms for familial erythroblastic


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