0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |

ATTEMPTS TO ENHANCE VIRULENCE OF HAEMOPHILUS PERTUSSIS BY SERIAL PASSAGE IN MICE

LYON P. STREAN, PH.D., D.D.S.
Am J Dis Child. 1943;65(6):895-897. doi:10.1001/archpedi.1943.02010180071008.
Text Size: A A A
Published online

In 1940 Strean1 described the use of pertussis endotoxin as a cutaneous test to determine susceptibility to pertussis. In subsequent publications the same author2 described the preparation and properties of pertussis endotoxin and clinical studies in immunity to pertussis with the use of pertussis-skin-testing toxin and antiendotoxin. This work has been confirmed, in the main, in recent publications by Lapointe3 and Evans.4

Since the potency of the toxin produced by Haemophilus pertussis phase I seems to parallel the virulence of the organism,5 an attempt was made to enhance the virulence by serial passage in mice.

In these experiments six strains of H. pertussis phase I were used, ranging in age from 6 months to 6 years and cultivated on modified Bordet-Gengou medium for approximately forty to five hundred generations. The organisms grown on modified Bordet-Gengou medium responded to all the tests for a smooth phase

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();