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ATTEMPTS TO ENHANCE VIRULENCE OF HAEMOPHILUS PERTUSSIS BY SERIAL PASSAGE IN MICE

LYON P. STREAN, PH.D., D.D.S.

Am J Dis Child. 1943;65(6):895-897. doi:10.1001/archpedi.1943.02010180071008.

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In 1940 Strean¹ described the use of pertussis endotoxin as a cutaneous test to determine susceptibility to pertussis. In subsequent publications the same author² described the preparation and properties of pertussis endotoxin and clinical studies in immunity to pertussis with the use of pertussis-skin-testing toxin and antiendotoxin. This work has been confirmed, in the main, in recent publications by Lapointe³ and Evans.⁴

Since the potency of the toxin produced by Haemophilus pertussis phase I seems to parallel the virulence of the organism,⁵ an attempt was made to enhance the virulence by serial passage in mice.

In these experiments six strains of H. pertussis phase I were used, ranging in age from 6 months to 6 years and cultivated on modified Bordet-Gengou medium for approximately forty to five hundred generations. The organisms grown on modified Bordet-Gengou medium responded to all the tests for a smooth phase

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STREAN LP. ATTEMPTS TO ENHANCE VIRULENCE OF HAEMOPHILUS PERTUSSIS BY SERIAL PASSAGE IN MICE. Am J Dis Child. 1943;65(6):895-897. doi:10.1001/archpedi.1943.02010180071008.

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