This monograph is a terse, scholarly attempt to explain the nature and development of degenerative joint disease. The work was started in 1930 at the Harvard Medical School and the Massachusetts General Hospital in connection with the Robert W. Lovett Memorial Association, with the aim of gathering information concerning the anatomy and physiology of articulations and the nature of the diseases disturbing them. In addition, not only were detailed clinical studies of arthritic patients made from the important standpoint of pathology, but bacteriologic, metabolic and neuropathologic observations were included.
Knee joints were obtained post mortem or after amputation from patients ranging in age from 1 month to 90 years who, so far as was known, had no history or clinical evidence of articular disease. The joints were first examined roentgenologically; then they were opened for both macroscopic and microscopic examination. It was thus revealed that all the joints obtained from