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SYNDROME OF CUTANEOUS FRAGILITY AND HYPERELASTICITY AND ARTICULAR HYPERLAXITY

BEN BENJAMIN, M.D.; HYMAN WEINER, M.D.
Am J Dis Child. 1943;65(2):247-257. doi:10.1001/archpedi.1943.02010140055004.
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A syndrome characterized by laxity and a hemorrhagic tendency of the skin and laxity of some joints was the subject of a communication by Ehlers1 in 1901. Cohn2 demonstrated a patient with laxity and peculiar circumscribed changes of the skin in 1907. A year later Danlos3 reported a case of laxity of the skin with tumors about the elbows and knees resulting from chronic contusions. Since then additional instances of this syndrome with all or some of its characteristic features have been described. A review of the subject in 1936 was made by Ronchese,4 who collected 24 published cases which he included under the heading of this syndrome and added the case reports of 3 children whom he observed, bringing the total to 27. A number of other cases have been recorded.5

We propose to describe what we feel is is a typical instance of the

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