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ATTEMPTS TO PRODUCE ABSORPTION OF POLIOMYELITIS VIRUS BY PERIPHERAL NERVES IN VITRO

JOHN A. TOOMEY, M.D.; LINDA A. TISCHER, M.D.; WILLIAM S. TAKACS, B.S.
Am J Dis Child. 1942;64(6):1008-1013. doi:10.1001/archpedi.1942.02010120048004.
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In preliminary experiments, peripheral nerves of rachitic animals were ground with purified eluted poliomyelitis virus. The supernatant fluid was found to be noninfectious, while the centrifugate produced the disease. When well medullated nonrachitic peripheral nerve fibers were ground with eluted virus, the supernatant fluid was found to be infectious and the centrifugate noninfectious. The evidence was interesting though not conclusive, since so few animals were used in each experiment that chance might explain the results. However, the lead was important enough to follow; if the conclusion could be confirmed it might then be inferred that the disease would be contracted if the medullated fibers of peripheral nerves were disturbed in some manner. Plans were made to repeat these experiments with a sufficient number of animals to make the results conclusive.

The objective was to determine whether there is any difference between the absorptive power of rachitic and that of nonrachitic

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