We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Case Reports |


Am J Dis Child. 1942;64(4):689-696. doi:10.1001/archpedi.1942.02010100115011.
Text Size: A A A
Published online


In 1823 a case of chloroma was first reported by Allan Burns. In 1893, on the basis of the blood picture, Dock 1 first pointed out the relationship of chloroma and leukemia, and in 1904 Dock and Warthin2 definitely established this relationship. They defined chloroma as "a tumor-like hyperplasia of the parent-cells of the leucocytes, primary in the red marrow, the periosteum being involved only secondarily." Ewing3 has further emphasized the tumor-like properties of the process by stating that "the chief significance of chloroma lies in the fact that it represents a leukemic process of a pronounced neoplastic type. The bulky tumors, the destructive local infiltrations, the distant heterotopic metastases, the atypical character of the cells and their very active proliferation provide all the essential features of a malignant neoplasm." In 1930 Washburn4 had collected 162 cases from the literature between 1923 and 1929. In 1937 Kandel


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.