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Am J Dis Child. 1942;63(6):1110-1122. doi:10.1001/archpedi.1942.02010060094006.
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This is a statistical investigation of nonperforating and of perforating appendicitis, an attempt being made (1) to correlate the laboratory findings with the pathologic changes, morbidity and mortality, (2) to determine the incidence of chronic appendicitis in children and (3) to determine whether newer methods of treatment have produced a decreased morbidity and mortality in recent years.

CLINICAL MATERIAL  The study was made on a total of 918 children with appendicitis, 12 years of age or younger, who were admitted to the Israel Zion Hospital, Brooklyn, from January 1934 through September 1940. In view of the changes in therapy produced by the advent of sulfanilamide and its derivatives, the patients are divided into two groups—those treated before and those treated after January 1936.The incidence of appendicitis in infancy was relatively low, and the frequency increased proportionately throughout childhood into adolescence. During the


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