Progress in Pedatrics |


Am J Dis Child. 1942;63(3):552-580. doi:10.1001/archpedi.1942.02010030122009.
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NUTRITIONAL DEFICIENCY AND NUTRITIONAL EDEMA  The terms nutritional deficiency and deficiency disease include an extremely wide field. Generally speaking, they are applied to conditions caused by deficiency of some of the materials essential for adequate nutrition, such as fat, carbohydrate, protein, vitamins and minerals. There are thirty-six known such essential constituents of the diet, and it is likely that there are others as yet unknown. It is easily conceivable that pure deficiency of one essential substance probably never exists except in experimental animals, while the ordinary clinical nutritional deficiency states are caused by a lack of several essential substances, with one or more of the clinical deficiency syndromes more apparent than the others. Moreover, the question is even more complicated than this, since little significant information has been obtained concerning the body's requirements for certain of these factors, and even less is known of the interrelation of many of these


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