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Case Reports |

SEPTIC THROMBOPHLEBITIS OF THE CAVERNOUS SINUS IN A TWO YEAR OLD CHILD, WITH RECOVERY

MORRIS COHEN, M.D.; HARRY J. COHEN, M.D.
Am J Dis Child. 1942;63(3):546-551. doi:10.1001/archpedi.1942.02010030116008.
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Septic thrombophlebitis of the cavernous sinus secondary to infection of the face or nose was formerly a uniformly fatal disease. In 1936 Grove1 after surveying the literature concluded that the mortality was 100 per cent. Within the past two years there have been several recoveries following the use of sulfanilamide and its derivatives alone or in combination with heparin. Barnshaw,2 Seydell3 and Pace4 each reported a cure following the use of sulfanilamide; Morrison and Schindler,5 one following treatment with sulfapyridine (2-pparaaminobenzenesulfonamido]-pyridine), and C. T. and W. C. Wolfe,6 one following the use of sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole). Schall7 observed 3 cures obtained by the combined use of sulfathiazole and heparin. Erschler and Blaisdell,8 who also used the combined method, reported a cure which was complicated by massive hematuria secondary to the treatment with heparin. The following report is of a recovery in a 2

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