We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |


Am J Dis Child. 1942;63(2):225-237. doi:10.1001/archpedi.1942.02010020010002.
Text Size: A A A
Published online

Pnrophylaxis against diphtheria is universally recommended; prophylaxis against whooping cough is now generally accepted; and prophylaxis against tetanus has been found effective, although it has not been used routinely. The combined prophylaxis against two of the three diseases—diphtheria and tetanus—has been in use for several years.1 This paper records my experience with the combined prophylaxis against the three diseases—diphtheria, tetanus and whooping cough.

Theoretically, this triple immunization would present two advantages: first, possible adsorption of the toxoids and toxins by bacterial suspension, thus affording what Ramon2 has called a larger "effective antigenic surface;" second, nonspecific enhancement of antigen production, termed by Ramon "antigenic synergy." As an example of antigenic enhancement produced by the mixture of a toxoid with a bacterial vaccine, the work of Schütze3 is of interest. He immunized guinea pigs with mixtures of alum-precipitated diphtheria toxoid and whooping cough vaccine and reported the antigenic


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.