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November 1941, Vol 62, No. 5 >
Case Reports | November 1941

PYLORIC STENOSIS IN NONIDENTICAL TWINS

FRANCIS T. O'DONNELL, M.D.; JOSEPH M. KLEIN, M.D.
Am J Dis Child. 1941;62(5):1025-1028. doi:10.1001/archpedi.1941.02000170119010.
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The occurrence of malformations in twins has always incited the interest of medical observers. In the last two decades such malformations have been of special note in view of the introduction of the theory of genetic pathogenesis of some tumors. The incidence of congenital pyloric stenosis in twins has been a bulwark in the defense of this theory because it has indicated few exceptions to the general axiom that "heterologous twins never suffer from identical malformations, nor does one of homologous twins ever suffer from malformation not shared by its fellow."1

There have been many cases to suggest and to give support to the belief that there is a genetic basis for pyloric stenosis, the exact nature of which is not known. The fact that in four fifths of the cases the disease occurs in males attests to that, as does the report of Fabricius and Vogt-Møller2 on

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