With the recognition that rickets-like lesions may be found in association with derangements of metabolic processes, various syndromes of late rickets have been delineated, and the mechanisms involved have been subjected to study. In the clinic of the Children's Hospital we have had the opportunity during the past fifteen years to observe a number of children with late rickets and have been struck with the diversity of clinical patterns they have presented. Whereas certain groupings can be made on the basis of the apparent cause of the disorder, each patient has merited individual study because of the manner in which he has reacted to his difficulty. In general, the active rickets has seemed to be less significant in the patient's ultimate welfare than the underlying disturbance in metabolism.
The cases of some of the patients studied in this connection have been reported, and those of some others have been cited