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EPIPHYSIAL DYSGENESIS ASSOCIATED WITH HYPOTHYROIDISM

LAWSON WILKINS, M.D.
Am J Dis Child. 1941;61(1):13-34. doi:10.1001/archpedi.1941.02000070022002.
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Clinical reports of the abnormalities of epiphysial ossification which occur in hypothyroidism during childhood have been recorded in the Swiss or German literature by Läwen1 in 1909 (1 case), Roth2 in 1918 (3 cases), von Seemen3 in 1928 (2 cases) and Looser4 in 1929. Von Seemen called the condition "osteochondropathia cretinoidea." Looser described the abnormal structure of the epiphyses in 20 of 30 cretins whom he examined in Switzerland. In 1927 Fairbank,5 in England, reported instances of dwarfism with "stippled epiphyses" but failed to recognize the thyroid disturbance. There are few reports in the American literature. Brailsford,6 in 1935, mentioned 1 case in a monograph on radiology. Cavanaugh, Shelton and Sutherland,7 in 1936, reported 5 cases of osteochondritis of the capital femoral epiphyses which they considered due to hypothyroidism. However, in all their cases the condition was unilateral, dysgenesis was not found in

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