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Am J Dis Child. 1940;60(5):1043-1057. doi:10.1001/archpedi.1940.02000050027004.
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It has been found and reported by me,1 as well as by others,2 that too intensive treatment with chorionic gonadotropin, given for sexual underdevelopment, produces in some patients precocious secondary sexual characteristics. In view of this fact, it is important to know what specific effects intensive treatment, or for that matter what effects nonintensive administration of chorionic gonadotropin, has on height and osseous development as well as on sexual development.

In a recent paper1a on my observations on the skeletal changes produced in 9 young boys, between the ages of 3 years 3 months and 8 years, who were given varying doses of chorionic gonadotropin for sexual underdevelopment, I reported that height was increased and ossification was accelerated in most of the patients.

I also reported that 8 of the boys in this series (the exception is the youngest, who is now only 6 years old) have


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