This study is the result of ten years' observation of 62 patients who have had thyrotoxicosis during the past twenty-five years. Nearly all the patients have been followed for nine years in conjunction with the thyroid committee of the university clinic. The hyperthyroidism was definitely marked and not mild. Neither the forme fruste, or latent type, nor the relatively transitory simple hypertrophy occurring at puberty is included. One of the accomplished purposes of the study was the observation of most of the patients some years after full arrest had occurred and of a few when the disease was still active. Thus, something of the natural course of the disease was determined, and the therapy was appraised. The number of cases is too small to prove the validity of the observations. For clarity, nevertheless, the following impressions are very likely.
NATURAL COURSE OF THE DISEASE
The onset of the disease may