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Congenital Malformations: A Study of Parental Characteristics with Special Reference to the Reproductive Process.

Am J Dis Child. 1940;59(3):682. doi:10.1001/archpedi.1940.01990140225020.
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This book is the report of a study of 1,476 malformed infants in 890 families for a period covering five years. The results are presented by means of tables and are of great interest. Some high points are that gross congenital malformations afflict 1 in 213 children born alive and that about 25 per cent of congenitally malformed persons are stillborn. The study revealed a probability twenty-five times greater than normal that parents who already have 1 malformed child will bear another, but it showed no relation to social status, chronic illness, syphilis, season of the year, occupation of the parents, contraceptive methods or pelvic irradiation during pregnancy. The diets of the mothers of the defective children were found to be significantly lacking in calcium, phosphorus, iron and vitamins B, C and D. Many other results of the study are intensely interesting and should be read in full by any


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