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TREATMENT OF IMPETIGO CONTAGIOSA WITH RUBBER CONTAINING 8-HYDROXYQUINOLINE

MORTON SELDOWITZ, M.D.
Am J Dis Child. 1940;59(1):67-75. doi:10.1001/archpedi.1940.01990120069006.
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It has been recently demonstrated by Kahn and Carroll1 that rubber containing 8-hydroxyquinoline exhibits certain bacteriostatic properties, particularly in reference to the staphylococcus. Furthermore, this compound distributes itself between water and rubber in accordance with certain well known chemical laws. In view of the bacteriostatic properties of this rubber base combination, it occurred to me that the material might find therapeutic application in cases of certain types of pyogenic infections, mainly impetigo contagiosa. This particular disease was selected because it is common and because it is invariably pus producing. Though recognition is given to the fact that its cause has not been definitely established, cultures of material from the fresh lesions in this investigation have invariably produced staphylococci. For convenience, I shall refer to the medicated material merely as the rubber base substance or as medicated rubber.2

CLINICAL TYPES  In order to determine the therapeutic value of this

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