This discussion of the acid-soluble phosphorus compounds of the red blood cells concerns chiefly their importance in the acid-base equilibrium of the blood and their probable role in the intermediate phosphorus metabolism of the body. It is based on clinical and experimental studies of a variety of conditions in which large changes in the concentration of acid-soluble phosphorus in the blood cells are found. Examples from these studies are presented to demonstrate the changes which have been found associated with rickets, bilateral nephrectomy, alkalosis of pyloric obstruction and different types of acidosis. As a basis for the interpretation of the findings in these conditions, current concepts of the glycolytic cycle in blood are summarized briefly, since the reactions of the glycolytic process are responsible for the synthesis and hydrolysis of the organic phosphorus compounds with which these studies are concerned.
Values for inorganic and organic acid-soluble phosphorus were determined