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October 01, 1939, Vol 58, No. 4 >
Other Articles | October 01, 1939

EXPERIMENTAL ASTHMA

BRET RATNER, M.D.
Am J Dis Child. 1939;58(4):699-733. doi:10.1001/archpedi.1939.04380010009002.
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Among students of allergy there is a definite cleavage between those who believe in the close parallelism between animal anaphylaxis and human allergy and those who believe that the manifestations of the two conditions, although they may be similar, are mediated by different mechanisms. It has been contended that the anaphylactic state induced in the experimental animal solely through a parenteral introduction of antigen gives rise to an acute violent reaction which is not comparable to the usually sublethal allergic state in a human being. Consequently, in the study of allergic asthma investigators were actuated to devise modifications of the anaphylaxis test which would be more consonant with conditions in the human subject. Liquid or dry antigens were either instilled or insufflated into the nares or were naturally inhaled in the form of a spray.

My associates and I believed that liquid antigens do not provide the ideal medium for

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