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Am J Dis Child. 1939;58(3):540-557. doi:10.1001/archpedi.1939.01990090094007.
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Hyperparathyroidism is due to hyperfunction of one or more parathyroid glands. Clinically it is characterized by muscular weakness, polyuria, pain in the bones and skeletal changes, which vary from slight kyphosis to marked shortening of stature and deformity of the extremities. Renal colic resulting from stones, diarrhea and loss of appetite may also be present. The fundamental roentgen change is decalcification, which may be merely uniform osteoporosis or may be associated with cysts in the medullary portion or below the periosteum. Frequently calcification is seen in the soft tissues. The ultimate criteria for diagnosis have been an increase of serum calcium and a decrease of serum phosphorus together with an increase in urinary excretion of calcium. The serum phosphatase activity is usually elevated.

The development of this concept of hyperparathyroidism is extremely interesting, particularly when one considers that it is the result of individual contributions of many clinicians and experimental


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