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EFFECT OF YEAST EXTRACT (VITAMIN B COMPLEX) ON GROWTH AND DEVELOPMENT OF PREMATURE INFANTS

H. R. LITCHFIELD, M.D.; J. LICHTERMAN, M.D.; I. KNOLL, M.D.; I. KURLAND, M.D.
Am J Dis Child. 1939;57(3):546-553. doi:10.1001/archpedi.1939.01990030060006.
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Cowgill, Rosenberg and Rogoff1 observed in animal experimentation that in dogs subsisting on a diet deficient in vitamin B anhydremia rapidly developed. The observation that the administration of the vitamin B complex in appreciable amounts along with subcutaneous clysis results in definite retention of fluids in the body gave us a clue to the use of the vitamin B complex in the feeding of premature infants. In the treatment of marasmic infants who present evidences of dehydration, it is rather common practice to inject large amounts of fluids, but often with poor results. In the light of our present knowledge, it appears possible that in certain cases this practice may be really harmful unless the vitamin B complex is given at the same time.

Hoobler2 found in many infants a syndrome which he described as indicative of a lack of antineuritic vitamins. The features of the symptom complex

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