This excellent monograph is based on the results of several years of follow-up study on children in a series of tuberculous families. Approximately three fourths of its 225 pages are devoted to important observations made on the members of ten selected household units. One hundred and seventy-three references to pertinent literature are included.
Dr. Paul observed during the course of his study that tuberculosis appeared in an irregular fashion in different age groups. Variations in intercurrent nontuberculous infections, in environmental conditions, in constitutional characteristics and in the degree of exposure to open cases were among the factors apparently concerned in the lack of uniformity displayed by the course of the disease in different members of a family unit.
The manifestation of tuberculosis was characterized by extreme variability, the disease ranging through numerous transitional stages from conditions in which a positive tuberculin reaction constituted the sole evidence of infection to a