In a survey of the entire male population of the Polk State School for Mental Defectives, 12 of 1,608 patients were found to exhibit girdle type adiposity. The survey was initiated because we had been impressed by the occurrence in certain mentally deficient males of girdle type adiposity associated with various other stigmas commonly observed with two recognized clinical syndromes, namely, the Laurence-Moon-Biedl syndrome and the Fröhlich syndrome. Three questions arose which served to fix our attention on this investigation: 1. Are these two syndromes related or distinct? 2. Are they actual clinical entities or merely anatomic and physiologic manifestations of disease produced by many and varying etiologic factors? 3. Should the two syndromes continue to occupy a place in medical literature as clinical entities?
The following cases are presented not as proof of any theory but as a stimulus to further investigation of these problems. In the discussion we