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Am J Dis Child. 1937;54(5):1005-1011. doi:10.1001/archpedi.1937.01980050035004.
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In the clinical management of diabetes mellitus, adequacy of control is best gaged by the degree of oscillation of the blood sugar level during twenty-four hours. Basing interpretations on single estimations of the blood sugar is almost as unsafe as depending on isolated urinalyses as a basis for assurance that satisfactory management is being maintained. The occurrence of nocturnal hyperglycemia is usual after the disease is well established, but the part that this endogenous elevation of the blood sugar level plays in the hyperglycemia and glycosuria of later hours is frequently overlooked. In some clinics it is customary to determine the level of the blood sugar under fasting conditions, after the administration of insulin but before the ingestion of food, and at various intervals after the ingestion of a meal. With such information and a constancy of regimen, a fair estimate can be formed as to the status of control


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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