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PROPHYLACTIC AND THERAPEUTIC USE OF SCARLET FEVER CONVALESCENT SERUM

CLARENCE M. HYLAND, M.D.; LUCILE RUSSELL ANDERSON, M.D.
Am J Dis Child. 1937;54(3):504-519. doi:10.1001/archpedi.1937.01980030048003.
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Scarlet fever is essentially a disease of children, but their susceptibility to it is much lower than their susceptibility to measles. According to reports, susceptibility to scarlet fever varies from 19 to 100 per cent, depending on the age group and the class to which the patient belongs. It is higher in the well-to-do classes, and it decreases with increasing age, as do the morbidity and the mortality. Zingher1 made cutaneous tests on 300 children in a private school in New York and found that 83 per cent of the children under 18 years of age reacted to scarlet fever toxin. Johannessen2 reported that of 185 children under 15 who were exposed to scarlet fever, 28 per cent contracted it, while of 314 exposed adults, only 5 per cent had the disease. At least half the cases occur in children between 3 and 8 years old, and 90

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