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HUMAN CONVALESCENT SERUM IN THE PREVENTION AND MODIFICATION OF MEASLES

CLARENCE M. HYLAND, M.D.; LUCILE RUSSELL ANDERSON, M.D.
Am J Dis Child. 1937;54(2):277-287. doi:10.1001/archpedi.1937.01980020071006.
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Measles is possibly the most prevalent, the most contagious and one of the most fatal diseases of early childhood. Practically all human beings are susceptible, regardless of their age or race or the climate in which they live, but young children furnish the greatest number of cases and the highest mortality. Ninety-seven per cent of the cases occur before the age of 15 and over one-half during the first five years of life. It is difficult to prevent exposure to the disease because of its highly contagious character in the prodromal period, during which the symptoms are not diagnostic and its nature remains unrecognized. The period of highest infectivity is in the preeruptive stage. Few persons die of the disease itself, but, contrary to the popular conception, measles is a disease to be feared because of the high mortality due to complications from secondary invading organisms. The death rate from

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