Carrière is professor of medicine at the University of Lille. He writes clearly and concisely and reveals himself a careful observer and investigator. He has had the opportunity of studying large numbers of patients with diphtheria and is well fitted to describe not only the usual clinical picture of the disease but also the more rare manifestations. The effect of associated infections on the course of diphtheria are considered and also the manifestations of the diphtheria which develops in the course of other infections, such as scarlet fever and measles. Considerable attention is paid to the disturbances of the vascular system associated with diphtheria, and there is a brief discussion of the various forms of paralysis which may develop.
In discussing serum therapy, the author expresses the opinion that massive doses may be harmful and states definitely that 500 units of antitoxin per kilogram of body weight is sufficient. Theoretically,