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Am J Dis Child. 1936;52(2):331-344. doi:10.1001/archpedi.1936.04140020074008.
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Excellent clinical and anatomic descriptions of pulmonary gangrene were made as early as 1808 by Laennec.1 Not long after the introduction of good microscopes, spiral organisms, probably oral spirochetes, were observed in pulmonary gangrene by Leyden and Jaffe (1867).2 Recent investigations of the disease date from the report of Rona,3 who in 1905 called attention to the presence of spirochetes in pulmonary gangrene and stated that carious teeth were the probable source of these organisms. Numerous other observers have since reported the presence of oral spirochetes in pulmonary gangrene, and the microbic nature of the disease has been established by the experimental production of gangrene in lower animals (Veszpremi,4 Loygue, Bonnet and Peyre,5 Kline,6 Pilot and Davis7 and Smith8). In 1923 Kline6 produced gangrene in guinea-pigs by the injection into traumatized tissue of material not only from pulmonary gangrene but also from


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