The high concentration of fat in the adrenal cortex and its close association there with cholesterol have long been known. Recent investigations indicate that the cortical lipoids are intimately connected with vitamin C and raise the question as to the relationship of this vitamin to the depletion of fat in the adrenal cortex under certain pathologic conditions. In a few instances in this study it has been possible to compare the amount of titratable vitamin C with the amount of stainable fat. Such comparisons indicate that with the depletion of the lipoids there is a parallel reduction in vitamin C and that the decrease of the vitamin is roughly in direct proportion to the decrease of the lipoid content.
A wealth of observations have been published on the effects of infection on the fat content of the adrenals. Three articles have been published dealing exclusively with alterations in the lipoid