Sickle cell anemia and the sickling phenomenon are generally considered to be found only in Negroes or in persons having an admixture of Negro blood. A review of the literature, however, shows reports of several cases in which the possibility of Negro blood in the patient is remote.
Archibald1 reported a case of sickle cell anemia in an Arab, and Stewart2 reported one in a Cuban; in neither could the possibility of Negro blood be excluded. On the other hand, Castana3 reported a case of sickle cells in an Italian child, and Cooley and Lee4 reported a typical case in a Greek child, in whom the possibility of Negro blood was improbable. Rosenfeld and Pincus5 described an instance of a child of Mediterranean parentage with sickle cell anemia, in whom the presence of Negro blood was not possible, as the family had lived in the