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Am J Dis Child. 1935;50(4):954-965. doi:10.1001/archpedi.1935.01970100132012.
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The clinical manifestations and the anatomic features of the fully developed form of tuberous sclerosis are so well known and so fully described in textbooks1 that a brief résumé of the cardinal signs and a concise description of the more prominent anatomic alterations will meet the needs of this contribution.

A FEW CLINICAL REMARKS  The triad of typical symptoms, convulsive seizures, retarded or arrested mental development and adenoma sebaceum, a skin eruption characteristic in location and outline, is the striking feature of tuberous sclerosis, which insures the clinical recognition of this disease in the typical case. But there are cases, particularly among infants, which are not, and often cannot be, diagnosed correctly because one or more of the classic clinical features are lacking. Of this kind there are on record a number of verified cases. Two have come recently under our own observation, in which convulsive seizures were the


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