Multiple myeloma may be defined as a primary malignant tumor of bone marrow characterized by multiple foci in long and flat bones of the skeleton and usually associated with anemia, Bence-Jones proteinuria, rare metastasis and a fatal termination. Maclntyre1 described the condition in 1850, but von Rustizky2 first recognized it as a specific disease of the bone marrow, and referred to it as myeloma. Kahler,3 in 1889, called attention to the associated proteinuria, hence the reference in the literature to "Kahler's disease." Geschickter and Copeland,4 in 1927, reviewed 425 cases from the literature, and stated that multiple myeloma was present in only 0.03 per cent of all malignant conditions. Symmers5 found only three cases of the condition in the course of 6,000 postmortem examinations performed at Bellevue Hospital, New York City. Thus the rarity of multiple myeloma is evident.
The disease usually afflicts persons well