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Les paralysies diphtériques.

Am J Dis Child. 1933;46(1):231. doi:10.1001/archpedi.1933.01960010241026.
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The experimental studies of Dr. Pierre Uhry on diphtheritic paralyses are presented in this volume. Guinea-pigs, dogs and rabbits were used in the research. The behavior of these animals after injections of diphtheria toxin was carefully observed. The physiopathology and histopathology of the experimental paralysis as well as various methods of therapy were carefully studied. There were a few cases in which the pathologic changes of diphtheritic paralysis in man were available. An extensive bibliography is furnished. The author summarizes the results of his work in the following conclusions:

  1. Diphtheria toxin is the sole cause of the paralysis.

  2. The paralysis is due to toxic polyneuritis of the peripheral nerves in which degenerative changes are primary.

  3. The toxin is fixed in the nerves.

  4. The toxin acts on the nerve endings locally near the site of injection and also is absorbed in the blood stream, from where it


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