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PROGRESS IN PEDIATRICS |

SICKLE CELL ANEMIA

WILLIAM WILLIS ANDERSON, M.D.; ROBERT L. WARE, M.D.
Am J Dis Child. 1932;44(5):1055-1070. doi:10.1001/archpedi.1932.01950120137011.
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Since rational treatment may be developed only through a thorough knowledge of a disease, we are assembling and summarizing the information on the subject of sickle cell anemia, and including the reports of six cases that were studied at the Emory University Division of Grady (Municipal) Hospital in Atlanta.

HISTORICAL SURVEY  The disease was first described as a clinical entity by Herrick1 in 1910. However, in 1904, Dresbach2 reported a case of peculiar red cells occurring in a Negro medical student who turned in a sketch of his own blood as an assignment for laboratory work in histology. The instructor noted that the cells were drawn as elliptic rather than round shapes. This led to an investigation, and it was found that 90 per cent of the student's cells were elliptic, the length averaging two and a half times the width. At the time, the student had no

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